A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients
作者： Luciano Gattinoni , Luca Brazzi , Paolo Pelosi , Roberto Latini , Gianni Tognoni
DOI: 10.1056/NEJM199510193331601
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摘要: Background Hemodynamic therapy to raise the cardiac index and oxygen delivery supranormal levels may improve outcomes in critically ill patients. We studied whether increasing a level (cardiac-index group) or mixed venous saturation normal (oxygen-saturation would decrease morbidity mortality among patients, as compared with control group which target was index. Methods A total of 10,726 patients 56 intensive care units were screened, whom 762 belonging predefined diagnostic categories acute physiology scores 11 higher randomly assigned three groups (252 group, 253 cardiac-index 257 oxygen-saturation group). Results The hemodynamic targets reached by 94.3 percent 44.9 66.7 (P<0.001). Mortality 48.4, ...
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