Dose-Response Effects of Exercise on Glucose-Lowering Medications for Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.

摘要: Abstract Objective To investigate whether a dose-response relationship exists between volume of exercise and discontinuation glucose-lowering medication treatment in patients with type 2 diabetes. Patients Methods Secondary analyses randomized controlled exercise-based lifestyle intervention trial (April 29, 2015 to August 17, 2016). non–insulin-dependent diabetes were randomly assigned an intensive (U-TURN) or standard-care group. Both groups received advice objective target-driven medical regulation. Additionally, the U-TURN group supervised individualized dietary counseling. Of 98 participants, 92 included analysis (U-TURN, n=61, standard care, n=31). Participants stratified into tertiles based on accumulated volumes completed during 1-year intervention. Results Median levels 178 (interquartile range [IQR], 121-213; lower tertile), 296 (IQR, 261-310; intermediate 380 minutes per week 355-446; upper tertile) associated higher odds discontinuing medication, corresponding ratios 12.1 (95% CI, 1.2-119; number needed treat: 4), 30.2 2.9-318.5; 3), 34.4 4.1-290.1; 2), respectively, when comparing care. Cardiovascular risk factors such as glycated hemoglobin A1c levels, fitness, 2-hour glucose triglyceride improved significantly tertiles, but not tertile, compared Conclusion Exercise is dose-dependent manner, are important cardiovascular well-treated participants disease duration less than 10 years. Further studies support these findings. Study Registration ClinicalTrials.gov registration (NCT02417012).