Intratumoral Heterogeneity of Expression of 16 miRNA in Luminal Cancer of the Mammary Gland
作者： Yuliya A. Veryaskina , Sergei E. Titov , Vlada V. Kometova , Valerii V. Rodionov , Igor F. Zhimulev
DOI: 10.3390/NCRNA6020016
关键词:
摘要: The purpose of this work is to determine the intratumoral distribution miRNA expression profiles in luminal breast cancer (BC). study included 33 certain BC cases A or B (Her2-) subtypes. relative levels miRNA-20a; -21; -125b; -126; -200b; -181a; -205; -221; -222; -451a; -99a; -145; -200a; -214; -30a; -191; and small nuclear RNAs U6, U54, U58 were measured by RT-qPCR four intratumor areas each specimens surrounding normal mammary gland tissues. Comparative analysis between tissue different revealed that only miRNAs (miRNA-21, -200b, -200a, -191) appear as consistently differentiating markers. comparative tumor border statistically significant differences for ten miRNAs; 10 show differential central specimens; 9 periphery 1; 13 2. After comparing 1 center, we found five after 2 observed 12 miRNAs. MiRNA are subject considerable variation, depending on area. This may explain inconsistency estimates coming from laboratories.
mdpi.com
sci-hub.se 参考文章(39)
Andrea Feliciano, Josep Castellvi, Ana Artero-Castro, Jose A. Leal, Cleofé Romagosa, Javier Hernández-Losa, Vicente Peg, Angels Fabra, Francisco Vidal, Hiroshi Kondoh, Santiago Ramón y Cajal, Matilde E. LLeonart, miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-α, CCNJ, and MEGF9 PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0076247
Dario De Biase, Michela Visani, Luca Morandi, Gianluca Marucci, Cristian Taccioli, Serenella Cerasoli, Agostino Baruzzi, Annalisa Pession, PERNO Study Group, None, miRNAs Expression Analysis in Paired Fresh/Frozen and Dissected Formalin Fixed and Paraffin Embedded Glioblastoma Using Real-Time PCR PLOS ONE. ,vol. 7, pp. 123- 132 ,(2012) , 10.1371/JOURNAL.PONE.0035596
Stephanie B. Greene, Jason I. Herschkowitz, Jeffrey M. Rosen, The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer. RNA Biology. ,vol. 7, pp. 300- 304 ,(2010) , 10.4161/RNA.7.3.11837
Jian-Yi Li, Yang Zhang, Wen-Hai Zhang, Shi Jia, Ye Kang, Xiao-Yu Zhu, Differential distribution of miR-20a and miR-20b may underly metastatic heterogeneity of breast cancers. Asian Pacific Journal of Cancer Prevention. ,vol. 13, pp. 1901- 1906 ,(2012) , 10.7314/APJCP.2012.13.5.1901
Chun-Wen Cheng, Hsiao-Wei Wang, Chia-Wei Chang, Hou-Wei Chu, Cheng-You Chen, Jyh-Cherng Yu, Jui-I Chao, Huei-Fang Liu, Shian-ling Ding, Chen-Yang Shen, MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. Breast Cancer Research and Treatment. ,vol. 134, pp. 1081- 1093 ,(2012) , 10.1007/S10549-012-2034-4
N Zhang, X Wang, Q Huo, M Sun, C Cai, Z Liu, G Hu, Q Yang, MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin Oncogene. ,vol. 33, pp. 3119- 3128 ,(2014) , 10.1038/ONC.2013.286
Carlos Marino Cabral Calvano Filho, Daniele Carvalho Calvano-Mendes, Kátia Cândido Carvalho, Gustavo Arantes Maciel, Marcos Desidério Ricci, Ana Paula Torres, José Roberto Filassi, Edmund Chada Baracat, Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p. Tumor Biology. ,vol. 35, pp. 7733- 7741 ,(2014) , 10.1007/S13277-014-2025-7
Assia Derfoul, Aster H. Juan, Michael J. Difilippantonio, Nallasivam Palanisamy, Thomas Ried, Vittorio Sartorelli, Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase. Carcinogenesis. ,vol. 32, pp. 1607- 1614 ,(2011) , 10.1093/CARCIN/BGR184
Blenkiron C Goldstein LD Thorne NP, Spiteri I Chin SF, None, MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype Genome Biology. ,vol. 8, pp. 1- 16 ,(2007) , 10.1186/GB-2007-8-10-R214
S.-M. Park, A. B. Gaur, E. Lengyel, M. E. Peter, The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 Genes & Development. ,vol. 22, pp. 894- 907 ,(2008) , 10.1101/GAD.1640608