Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate
作者： John D. Belcher , Chunsheng Chen , Julia Nguyen , Ping Zhang , Fuad Abdulla
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摘要: Abstract Aims: Heme derived from hemolysis is pro-oxidative and proinflammatory promotes vaso-occlusion in murine models of sickle cell disease (SCD), suggesting that enhanced detoxification heme may be beneficial. Nuclear factor erythroid-2-related factor-2 (Nrf2) transcription pathway the principal cellular defense system responding to stress. Dimethyl fumarate (DMF), a drug approved for treatment multiple sclerosis, provides neuroprotection by activating Nrf2-responsive genes. We hypothesized induction Nrf2 with DMF would beneficial SCD models. Results: (30 mg/kg/day) or vehicle (0.08% methyl cellulose) was administered 3–7 days NY1DD HbSS-Townes mice. Vaso-occlusion, hallmark SCD, measured mice dorsal skinfold chambers, inhibited DMF. The inhibitory effect abrogated oxygenase-1 (HO-1) inhibitor tin protoporphyrin. increased nuclear mRNA Nrf2-...
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U. MULLER-EBERHARD, J. JAVID, H. H. LIEM, A. HANSTEIN, M. HANNA, Plasma Concentrations of Hemopexin, Haptoglobin and Heme in Patients With Various Hemolytic Diseases Blood. ,vol. 32, pp. 811- 815 ,(1968) , 10.1182/BLOOD.V32.5.811.811
T. H. Murphy, J. Yu, R. Ng, D. A. Johnson, H. Shen, C. R. Honey, J. A. Johnson, Preferential expression of antioxidant response element mediated gene expression in astrocytes. Journal of Neurochemistry. ,vol. 76, pp. 1670- 1678 ,(2001) , 10.1046/J.1471-4159.2001.00157.X
Paul Talalay, Cynthia A. Wilczak, Sharon R. Spencer, Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues. Cancer Research. ,vol. 50, pp. 7871- 7875 ,(1990)
Kai Takaya, Takafumi Suzuki, Hozumi Motohashi, Ko Onodera, Susumu Satomi, Thomas W. Kensler, Masayuki Yamamoto, Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. Free Radical Biology and Medicine. ,vol. 53, pp. 817- 827 ,(2012) , 10.1016/J.FREERADBIOMED.2012.06.023
Kathryn D. Held, Edward R. Epp, Edward P. Clark, John E. Biaglow, Effect of Dimethyl Fumarate on the Radiation Sensitivity of Mammalian Cells in Vitro Radiation Research. ,vol. 115, pp. 495- 502 ,(1988) , 10.2307/3577299
Joanne Walsh, Rosalind E Jenkins, Michael Wong, Adedamola Olayanju, Helen Powell, Ian Copple, Paul M O’Neill, Christopher EP Goldring, Neil R Kitteringham, B Kevin Park, None, Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications Journal of Proteomics. ,vol. 108, pp. 171- 187 ,(2014) , 10.1016/J.JPROT.2014.05.007
Ralf A. Linker, De-Hyung Lee, Sarah Ryan, Anne M. van Dam, Rebecca Conrad, Pradeep Bista, Weike Zeng, Xiaoping Hronowsky, Alex Buko, Sowmya Chollate, Gisa Ellrichmann, Wolfgang Brück, Kate Dawson, Susan Goelz, Stefan Wiese, Robert H. Scannevin, Matvey Lukashev, Ralf Gold, Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway Brain. ,vol. 134, pp. 678- 692 ,(2011) , 10.1093/BRAIN/AWQ386
John D. Belcher, Chunsheng Chen, Julia Nguyen, Liming Milbauer, Fuad Abdulla, Abdu I. Alayash, Ann Smith, Karl A. Nath, Robert P. Hebbel, Gregory M. Vercellotti, Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease Blood. ,vol. 123, pp. 377- 390 ,(2014) , 10.1182/BLOOD-2013-04-495887
Elizabeth R. Macari, Christopher H. Lowrey, Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood. ,vol. 117, pp. 5987- 5997 ,(2011) , 10.1182/BLOOD-2010-10-314096
Gregory M. Vercellotti, Fatima B. Khan, Julia Nguyen, Chunsheng Chen, Carol M. Bruzzone, Heather Bechtel, Graham Brown, Karl A. Nath, Clifford J. Steer, Robert P. Hebbel, John D. Belcher, H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice. Frontiers in Pharmacology. ,vol. 5, pp. 79- 79 ,(2014) , 10.3389/FPHAR.2014.00079