Plasma Renin Activity and Resting Heart Rate in a Population of Community-Dwelling Japanese: The Tanushimaru Study

摘要: BACKGROUND Heart rate is a strong predictor of mortality and development obesity diabetes. The renin-angiotensin-aldosterone system plays an important role in blood pressure control volume homeostasis. Although many studies have indicated the association between aldosterone hypertension or insulin resistance, epidemiological evidence heart with plasma renin activity (PRA) remains scant. Therefore, we investigated whether associated PRA. METHODS A total 1,943 subjects were enrolled, who underwent health examination Tanushimaru 2009. Plasma concentrations measured by radioimmunoassay. PRA homeostasis model assessment (HOMA) used natural-log transformed. Resting was using electrocardiography. RESULTS We divided into four groups (<60/min, 60-69/min, 70-79/min, ≥80/ min), analyzed analysis covariance after adjustments for age sex. adjusted mean HOMA index showed significant trend (P < 0.01) as higher rate, although there no = 0.26). In multiple linear regression age, sex, systolic pressure, index, hypertensive medication, positively strongly elevated 0.01). CONCLUSIONS This study demonstrated that PRA, but not aldosterone, significantly resting general population.