Classification and controversies in pathology of ependymomas.

摘要: PURPOSE: Bailey and Cushing established ependymoma as a brain tumour entity in the first classification (1926). Diagnosis of ependymomas is not subject to controversy long other tumours presenting ependymoma-like features have been ruled out. Grading conversely source debate. Description histological establishing diagnosis grading may help better understand this controversy. METHODS: Literature has reviewed using PubMed with following key words: ependymoma, +/- prognosis, biomaker, grading, immunohistochemistry, proliferative index. RESULTS: arises from elusive WHO individual characteristics including location, pattern/variant variable expression biomarkers. CONCLUSION: There need for scheme proven general ability dissociate grades, predict clinical evolution. Only then will stratified targeted therapeutics ependymal be possible.