Ubiquitin-immunoreactive filamentous inclusions in anterior horn cells of Guamanian and non-Guamanian amyotrophic lateral sclerosis.
作者： S. Matsumoto , A. Hirano , S. Goto
DOI: 10.1007/BF00294639
关键词:
摘要: Immunohistochemical studies with an antibody to ubiquitin revealed the presence of filamentous inclusions in spinal anterior horn cells all six patients Guamanian amyotrophic lateral sclerosis (ALS) and one cases parkinsonism-dementia complex (PD) on Guam. Similar ubiquitin-reactive were found seven non-Guamanian sporadic ALS examined. No similar seen normal controls or non-ALS who had chromatolytic neurons. The differed from neurofibrillary tangles, a characteristic feature PD, since they restricted did not react anti-tau antibody. neurons occasionally weak diffuse immunoreactivity, but no focal detected. These results suggest that may reflect degenerative process motor neuron disease.
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