The distribution of tau in the mammalian central nervous system.

作者: L I Binder , A Frankfurter , L I Rebhun

DOI: 10.1083/JCB.101.4.1371

关键词:

摘要: We have determined the biochemical and immunocytochemical localization of heterogeneous microtubule-associated protein tau using a monoclonal antibody that binds to all polypeptides in both bovine rat brain. Using immunoblot assays competitive enzyme-linked immunosorbent assays, we shown be more abundant white matter extracts microtubules than from an enriched gray region On per mole basis, twice-cycled contained three times did matter. Immunohistochemical studies compared with MAP2 tubulin demonstrated was restricted axons, extending results studies. Tau not observed glia, which indicated that, at least brain, is neuron specific. These observations indicate may help define subpopulation axons. Furthermore, described this report should prove very useful investigators studying axonal sprouting growth because it exclusive marker.

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