A Disintegrin and Metalloprotease 17 Mediates Neointimal Hyperplasia in Vasculature
作者： Akira Takaguri , Keita Kimura , Akinari Hinoki , Allison M. Bourne , Michael V. Autieri
DOI: 10.1161/HYPERTENSIONAHA.110.166892
关键词:
摘要: The requirement of a metalloprotease, disintegrin and metalloprotease 17 (ADAM17) for the growth cultured vascular smooth muscle cells has been demonstrated in vitro. However, whether this is responsible remodeling vivo remains unanswered. Rat carotid arteries were analyzed 2 weeks after balloon angioplasty. neointimal strongly positive ADAM17 immunostaining. Marked inhibition intimal hyperplasia was observed dominant-negative adenovirus-treated artery. Proliferating cell nuclear antigen-positive phospho-epidermal factor receptor-positive neointima reduced by as well. In contrast, formation, proliferating cells, markedly enhanced wild-type adenovirus. conclusion, activation involved epidermal receptor subsequent injury. could be novel therapeutic target pathophysiological remodeling.
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