Cytostatic Drug Resistance and Differentiation in Friend Erythroleukemia Cells

摘要: Cytostatic drug resistance is a common clinical problem in antitumor chemotherapy. To study mechanisms of resistance, vitro model systems have been established. Frequently cross-resistance to other cytostatic drugs (i.e., chemically and structurally not related the selective agent) was observed these cell lines [1]. Multidrug included medicaments often used therapy regimens such as vinca alkaloids or anthracyclines. Over-expression 170 kD glycoprotein found correlate with multidrugresistant phenotype [2, 3]. The gene encoding for glycoprotein, mdrl, has cloned sequenced [4, 5]. multidrug-resistant could be transferred drug-sensitive cells by transfection mdrl cDNA [6, 7]. Resistant showed significant lower intracellular levels, due an activated efflux mechanism [8, 9]. MDR overexpression detected several leukemias tumors poor prognosis [10–13].