The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein
作者： Kazumitsu Ueda , Marilyn M. Cornwell , Michael M. Gottesman , Ira Pastan , Igor B. Roninson
DOI: 10.1016/S0006-291X(86)80136-X
关键词:
摘要: The development of simultaneous resistance to multiple drugs in cultured cells occurs after selection for single agents. This multidrug-resistance phenotype is thought mimic human tumors treated with chemotherapy. Both the expression a membrane protein, termed P170 or P-glycoprotein, and cloned DNA fragment, mdr1, have been shown independently be associated cells. In this work, we show that KB carcinoma which express mdr1 gene also cDNAs encoding P-glycoprotein cross-hybridize cDNAs. Thus, codes P-glycoprotein.
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