Reduction of salivary flow with botulinum toxin: extended report on 33 patients with drooling, salivary fistulas, and sialadenitis.

摘要: Objectives/Hypothesis: The aim of the study was evaluation clinical data 33 patients who had drooling attributable to various diseases, salivary fistulas, and sialadenitis been treated with injection botulinum toxin type A (Botox). controlled follow-up documenting efficiency, possible side effects, duration effect treatment also performed. Study Design: Retrospective evaluation. Methods: Thirty-three head neck carcinoma, neurodegenerative stroke, or idiopathic hypersalivation fistula chronic received injections 20 65 U into glands under sonographic control. entire flow rate output per minute analytes thiocyanate, total protein, α-amylase, acid phosphatase, kallikrein, immunoglobulin were measured at times before after injection. examined regard severity their symptoms, including control investigation cephalic glands. Results: Twenty-six (79% all patients) reported a distinct improvement symptoms Seven noted return high salivation rates requested second 4 7 months. Duration varied widely among individuals. In general, thiocyanate dropped sharply within 1 week increased again period 12 16 weeks. Conversely, amylase outputs during this period, whereas other remained roughly constant. Sonography did not reveal any major changes in gland parenchyma, effects noted. Conclusion: Reduction drooling, by local proved be dependable therapy for these disorders, as shown present extended report on patients. Side observed. application lasted approximately 3 Based results, authors recommend choice problem drooling.