Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta.
作者： S. Lager , V.I. Ramirez , F. Gaccioli , T. Jansson , T.L. Powell
DOI: 10.1016/J.PLACENTA.2014.04.017
关键词:
摘要: Fatty acids can function as signaling molecules, acting through receptors in the cytosol or on cell surface. G-Protein Receptor (GPR)120 is a membrane-bound receptor mediating anti-inflammatory and insulin-sensitizing effects of omega-3 fatty acid docohexaenoic (DHA). GPR120 dysfunction associated with obesity humans. Cellular localization influence maternal protein expression placenta are unknown. Herein we demonstrate that predominantly expressed microvillous membrane (MVM) human level this MVM not altered by body mass index (BMI).
placentajournal.org 
researchgate.net 参考文章(16)
J.C. Challier, S. Basu, T. Bintein, J. Minium, K. Hotmire, P.M. Catalano, S. Hauguel-de Mouzon, Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. ,vol. 29, pp. 274- 281 ,(2008) , 10.1016/J.PLACENTA.2007.12.010
Nicholas P. Illsley, Zhi-Qiong Wang, Andrea Gray, Mary C. Sellers, Mark M. Jacobs, Simultaneous preparation of paired, syncytial, microvillous and basal membranes from human placenta. Biochimica et Biophysica Acta. ,vol. 1029, pp. 218- 226 ,(1990) , 10.1016/0005-2736(90)90157-J
Anne Liese Magnusson-Olsson, Susanne Lager, Bo Jacobsson, Thomas Jansson, Theresa L. Powell, Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency. American Journal of Physiology-endocrinology and Metabolism. ,vol. 293, ,(2007) , 10.1152/AJPENDO.00571.2006
AN Pathmaperuma, Paula Mana, SN Cheung, Kavitha Kugathas, Angeline Josiah, ME Koina, Amy Broomfield, Viviane Delghingaro-Augusto, DA Ellwood, JE Dahlstrom, CJ Nolan, Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction Placenta. ,vol. 31, pp. 230- 239 ,(2010) , 10.1016/J.PLACENTA.2009.12.013
Atsuhiko Ichimura, Akira Hirasawa, Odile Poulain-Godefroy, Amélie Bonnefond, Takafumi Hara, Loïc Yengo, Ikuo Kimura, Audrey Leloire, Ning Liu, Keiko Iida, Hélène Choquet, Philippe Besnard, Cécile Lecoeur, Sidonie Vivequin, Kumiko Ayukawa, Masato Takeuchi, Kentaro Ozawa, Maithé Tauber, Claudio Maffeis, Anita Morandi, Raffaella Buzzetti, Paul Elliott, Anneli Pouta, Marjo-Riitta Jarvelin, Antje Körner, Wieland Kiess, Marie Pigeyre, Roberto Caiazzo, Wim Van Hul, Luc Van Gaal, Fritz Horber, Beverley Balkau, Claire Lévy-Marchal, Konstantinos Rouskas, Anastasia Kouvatsi, Johannes Hebebrand, Anke Hinney, Andre Scherag, François Pattou, David Meyre, Taka-aki Koshimizu, Isabelle Wolowczuk, Gozoh Tsujimoto, Philippe Froguel, Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human Nature. ,vol. 483, pp. 350- 354 ,(2012) , 10.1038/NATURE10798
D. Lanoix, J. St-Pierre, A.-A. Lacasse, M. Viau, J. Lafond, C. Vaillancourt, Stability of reference proteins in human placenta: general protein stains are the benchmark. Placenta. ,vol. 33, pp. 151- 156 ,(2012) , 10.1016/J.PLACENTA.2011.12.008
Christina M. Scifres, Baosheng Chen, D. Michael Nelson, Yoel Sadovsky, Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts. The Journal of Clinical Endocrinology and Metabolism. ,vol. 96, ,(2011) , 10.1210/JC.2010-2084
Uriel Elchalal, W. Timothy Schaiff, Steven D. Smith, Eli Rimon, Ibrahim Bildirici, D. Michael Nelson, Yoel Sadovsky, Insulin and fatty acids regulate the expression of the fat droplet-associated protein adipophilin in primary human trophoblasts American Journal of Obstetrics and Gynecology. ,vol. 193, pp. 1716- 1723 ,(2005) , 10.1016/J.AJOG.2005.04.012
Saswata Talukdar, Jerrold M Olefsky, Olivia Osborn, Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends in Pharmacological Sciences. ,vol. 32, pp. 543- 550 ,(2011) , 10.1016/J.TIPS.2011.04.004
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki, Gozoh Tsujimoto, Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nature Medicine. ,vol. 11, pp. 90- 94 ,(2005) , 10.1038/NM1168