作者: Thomas J Webster
DOI: 10.1016/S0065-2377(01)27005-7
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摘要: Abstract Traditional materials utilized for orthopedic and dental applications have been selected based on their mechanical properties ability to remain inert in vivo; this selection process has provided that satifisfy physiological loading conditions but do not duplicate the mechanical, chemical, architectural of bone. The less than optimal surface conventional resulted clinical complications necessitate surgical removal many such failed bone implants due insufficient bonding juxtaposed Sufficient an implant (i.e., osseointegration) is needed minimize motion-induced damage surrounding tissues support conditions, criteria crucial success. Insufficient osseointegration can be caused by biomaterial new synthesis and/or match those bone; mismatch between may lead stress strain imbalances cause loosening eventual failure. Clearly, next generation biomaterials must possess both biocompatible promote similar Due unique properties, as well simulate three-dimensional architecture bone, one possible consideration with improved efficacy are nanophase materials. This chapter presents reports design, synthesis, evaluation increased efficacy.