An emerging water contaminant, semicarbazide, exerts an anti-estrogenic effect in zebrafish (Danio rerio).
作者： Su Gao , Wei Wang , Hua Tian , Xiaona Zhang , Linlin Guo
DOI: 10.1007/S00128-014-1305-7
关键词:
摘要: To determine the endocrine disrupting effect of semicarbazide, an emerging water contaminant, changes in transcript levels hepatic estrogen-response genes including vitellogenin-1 (vtg-1), estrogen receptor α (ERα), and β (ERβ) were measured male female zebrafish exposed to semicarbazide with or without exogenous 17β-estradiol (E2). Exposure for 96 h 28 days resulted no significant induction vtg-1, ERα, ERβ mRNA expression, indicating that has estrogenic effect. However, a remarkable anti-estrogenic was demonstrated: treatment decreases ERβ, as well gonadosomatic index level after days. Moreover, exposure significantly inhibited ERα by E2 when co-exposed
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