Apc deficiency predisposes to renal carcinoma in the mouse.
作者： Owen J Sansom , David F R Griffiths , Karen R Reed , Douglas J Winton , Alan R Clarke
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摘要: Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene murine epithelium. Mice homozygous for conditional Apc allele were intercrossed with mice transgenic Cre recombinase under control Cyp1A promoter, which delivers constitutive recombination within proportion cells Inactivation leads accumulation nuclear β-catenin and rapid development multiple dysplastic foci. Renal carcinoma was observed an earliest onset 4 months. This predisposition accelerated p53 deficiency, reducing 2 Compared other models kidney neoplasia, represents particularly disease, so implicates important role suppressing carcinoma.
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