Effect of a short-term fast on ketamine-xylazine anesthesia in rats.

摘要: Although ketamine-xylazine (KX) anesthesia is commonly used in rats, it often reported to have an inconsistent anesthetic effect, with a prolonged induction time, inadequate plane, or very short sleep time. Blood flow the liver known shift after meal perhaps explaining variability among rats variable prandial status. The current study tested hypothesis that period of fasting (3 h) prior intraperitoneal KX would provide shorter time recumbency, longer total and more consistent loss toe pinch response than fed rats. Two groups male Sprague-Dawley were blinded, crossover experiments. was administered at 2 different doses (50 mg/kg-5 mg/kg 70 mg/kg-7 mg/kg) ad libitum feeding 3-h fast. There no significant differences between response. We conclude for 3 h does not affect reduce