Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats

摘要: The main objective of this study was to compare the effects ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses. Three groups (n=6 rats/group) consisting 3, 6 12 months age were used. During anesthesia, animals monitored for heart rate, respiratory frequency, blood oxygen saturation, rectal temperature. corneal paw withdrawal reflex also examined during anesthesia. reflexes absent progressively longer durations with increasing age. Significant decreases cardiac frequency and, saturation occurred 6- 12-month-old animals. Respiratory returned normal end anesthesia; however, significant decrease persisted Rectal temperature decreased significantly only 3-month-old Pulmonary edema effusion 50% In conclusion, if ketamine-xylazine are used doses should be optimized subjects prior initiation research project.