Effects of some hepatic microsomal enzyme inducers and inhibitors on xylazine-ketamine anesthesia.

摘要: Various inducers and inhibitors of hepatic microsomal enzymes were studied for their effects on xylazine-ketamine anesthesia. Pretreatment Sprague-Dawley rats with chloramphenicol (100 mg/kg, ip), cimetidine ketoconazole (40 po), SKF 525-A (25 ip) significantly (p less than 0.05) increased the duration anesthesia in injected ketamine (45 im) xylazine (21 im). phenobarbital ip, once daily 4 days) did not affect significantly. The increase animals pretreated was accompanied by secondary respiratory distress about 6 hr following recovery from anesthesia, often leading to death within 24 hr. Lesions consisting extensive serous pleural effusion, alveolar edema rich macrophages pulmonary hilar hemorrhage found at necropsy. These results indicate that inhibition commonly used therapeutic agents during prolong anesthetic effect, or as a result concurrent pharmacotherapy, could have deleterious effects.