Cardiac hypertrophy and hypertrophic cardiomyopathy: Introduction and management

摘要: The magnitude of hypertrophic response the left ventricle to pressure overload is variable and likely mediated by genetic factors as well other identified mechanisms. Myocardial hypertrophy a common phenotype multiple cardiac disease entities. Left ventricular (LVH) causes significant morbidity mortality in adults. Increased key stimulus for development LVH hypertensive patients those with aortic valve stenosis through several molecular Hypertrophic cardiomyopathy (HCM) present 1 500 people general population most genetically transmitted cardiomyopathy. HCM can be caused more than 1,400 different mutations an autosomal dominant pattern. Many individuals affected are undiagnosed, do not experience lethal events or symptoms. However, who develop symptoms such dyspnea, angina, lightheadedness functional disability secondary heart failure stroke sudden death (SCD). majority treated medically initial aim reduction along reducing risk SCD. Therapy classified into medical, interventional/device, surgical treatments.