Metabolic regulation as a control for lipid disorders. II. Influence of (--)-hydroxycitrate on genetically and experimentally induced hypertriglyceridemia in the rat.

摘要: These studies were designed to determine whether genetically and experimentally induced hypertriglyceridemia correlated with hyperlipogenesis, inhibiting fatty acid synthesis would reduce serum triglyceride levels. Hypertrigylceridemia, resulting from genetic obesity in Zucker rats fructose feeding or Triton administration Charles River rats, was examined relation vivo rates of heatic synthesis, the influence (--)-hydroxycitrate (a potent competitive inhibitor ATP citrate lyase) on levels lipogenesis determined. obese demonstrated significantly increased triglycerides compared their lean litter mates; lipogenic circulating reduced markedly by oral (--)-hydroxycitrate. Fructose administered diet drinking water a which associated marked increase hepatic lipogenesis, both parameters. In contrast significant role that apparently played development rat fructose-fed rat, given intravenously produced rise could not be accounted for, an appreciate extent, synthesis. (--)-Hydroxycitrate equivalently Triton-treated nontreated rats.