Design, Development and Optimization of Nimesulide-Loaded Liposomal Systems for Topical Application

摘要: Nimesulide, a non-steroidal anti-inflammatory drug, was incorporated into multilamellar liposomes to improve its performance on topical administration. The drug loaded onto employing thin film hydration technique. Various process and formulation variables were investigated obtain the liposomal products of desired quality. Liposomes monitored for percent entrapment, after separating unentrapped by mini column centrifugation, vesicular properties (such as size distribution profile, morphological attributes agglomeration tendency), diffused through synthetic semipermeable membrane, leakage. Systematic optimization studies carried out using 32 factorial design select optimized composition with reference diffusion batch subjected permeation retention rat skin human cadaver skin. In comparison methanolic solution pure nimesulide, formulations found retain higher amounts nimesulide in Anti-inflammatory studies, carragenan-induced paw edema model, indicated significantly better liposomally entrapped marketed gel Carbopol containing nimesulide.