Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

摘要: Objective. Frusemide loaded calcium alginate micropellets, an oral microparticulate delivery system, was statistically optimized exhibiting prolonged therapeutic action minimizing its adverse effects. Methods. Ionotropic Gelation technique adopted employing 32 Factorial designs and keeping the entire process free from organic solvents. Physicochemical release characteristics of prepared formulations were studied, variations only in sodium (primary polymer) Acrycoat E30D (copolymer) dispersion. Result. Sodium predominant over all batches. Nonadditives or interaction observed to be insignificant. Multiple regressions produced second-order polynomial equation, predictive results obtained validated with high degree correlation. The vivo study applauded that micropellets frusemide can produce a much greater diuretic effect extended period 24 hours. Conclusion. This reveals potential single dose mathematically micro pellets formulation is sufficient management peripheral edema ascites congestive heart failure as well treatment chronic hypertension, leading better patient compliance, minimum experimentation time, proving far more cost-effective than conventional methods formulating dosage forms.