Preparation and Evaluation of Zidovudine-Loaded Sustained-Release Microspheres. 2. Optimization of Multiple Response Variables

摘要: The formulation of zidovudine-loaded (AZT-loaded) sustained-release microspheres was prepared and optimized using response surface methodology. objective to use this statistical procedure obtain a with overall properties. effect variables (emulsifier concentration, drug polymer ratio, composition the internal phase emulsion) on number systemically investigated. were t85, entrapment efficiency, yield, percentage loose crystals. A desirability function that combines these four constructed. second-order polynomial equation fitted data, resulting used predict responses in optimal region. All investigated found be highly dependent variables, strong interactions observed between variables. It optimum AZT can obtained at low levels SDS ethyl acetate concentrations intermediate ratio. An under experimental conditions evaluated for individual desirability. values agreed predicted values.