Role of Protamine Disulphide Cross-Linking in Counteracting Oxidative Damage to DNA

摘要: Free radical (oxygen and nitrogen-derived)-induced sperm DNA damage may take place during the process of spermatogenesis, transit through epididymis, in distal seminal ducts male genital tract vitro processing. radical-induced spermatogenesis result strands highly sensitive telomeric sequences. Post-testicular epididymis is considered one main causes damage. Release oxygen radical-producing immature spermatozoa into seminiferous tubules mature co-migration epididymis. free also proximal portion radicals such as superoxide anion that leak from redox recycling mechanisms involved disulphide bond cross-­linking protamines flagellar proteins; cauda produced by epithelial cells;