Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders.

摘要: Over the last decade, a subfamily of G protein-coupled receptors that are agonized by endogenous and dietary free-fatty acids (FFA) has been discovered. These acid include FFA2 FFA3, which short-chained FFA, as well FFA1 FFA4, medium-to-long chained FFA. Ligands for FFA4 comprise family long chain polyunsaturated omega-3 fatty including α-linolenic (ALA), eicosapentaenoic (EPA), docosahexaenoic (DHA), suggesting many long-known beneficial effects these fats may be receptor mediated. In this regard, gathered considerable interest due to its role in ameliorating inflammation, promoting insulin sensitization, regulating energy metabolism response FFA ligands. The goal review is summarize body evidence regard signal transduction, mechanisms regulation, functional variety tissues. addition, recent endeavors toward discovery small molecules modulate activity also presented.