Biochemical storage lesions occurring in nonirradiated and irradiated red blood cells: a brief review.

摘要: Red blood cells undergo a series of biochemical fluctuations during 35–42-day storage period at 1°C to 6°C. The sodium/potassium pump is immobilised causing decrease in intracellular potassium with an increase cytoplasmic sodium levels, glucose levels decline, and acidosis occurs as result low pH levels. frailty stored erythrocytes triggers the formation haemoglobin-containing microparticles release cell-free haemoglobin which may add transfusion difficulties. Lipid peroxidation, oxidative stress band 3 structures, other morphological structural molecular changes also occur leading spheroechinocytes osmotic fragility. These that transpire red are referred “storage lesions.” It well documented gamma irradiation exacerbates lesions reports increased adverse reactions observed neonates infants have been particular concern. There are, however, remarkably few systematic studies comparing vitro irradiated nonirradiated cell concentrates it has suggested impact on leucocyte reduced concentrate (RBCC) incomplete. review examines their effects reference transfusion.