Normal-Karyotype Acute Myeloid Leukemia

作者: R.P. Hasserjian

DOI: 10.1016/B978-0-12-386456-7.04103-4

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摘要: Acute myeloid leukemia (AML) is an aggressive neoplasm characterized by arrest of hematopoietic maturation, resulting in increased myeloblasts the blood and bone marrow. Current treatment strategies for AML are based on both patient-related parameters such as age performance status intrinsic disease biology. The latter heavily influenced genetic abnormalities present stem cells. Traditionally, cytogenetic were paramount determining prognosis; however, about 40% AMLs have a normal karyotype. In recent years, rapidly increasing information becoming available regarding gene mutations normal-karyotype their influence prognosis. Key exhibit complex interactions with one another also epigenetic alterations driving Future therapies will increasingly rely signatures individual leukemias future adjust therapy to predicted aggressiveness employ targeted against particular deregulated pathways.

参考文章(60)
Vardiman J, Matutes E, Bennett J, D Head, Brunning Rd, Flandrin G, Harris Nl, Acute myeloid leukaemia with recurrent genetic abnormalities. . IARC Press. ,(2001)
Raynier Devillier, Véronique Gelsi-Boyer, Mandy Brecqueville, Nadine Carbuccia, Anne Murati, Norbert Vey, Daniel Birnbaum, Marie-Joëlle Mozziconacci, Acute myeloid leukemia with myelodysplasia-related changes are characterized by a specific molecular pattern with high frequency of ASXL1 mutations. American Journal of Hematology. ,vol. 87, pp. 659- 662 ,(2012) , 10.1002/AJH.23211
S J Kussick, D L Stirewalt, H S Yi, K M Sheets, E Pogosova-Agadjanyan, S Braswell, T H Norwood, J P Radich, B L Wood, A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication Leukemia. ,vol. 18, pp. 1591- 1598 ,(2004) , 10.1038/SJ.LEU.2403458
Amir T Fathi, Laurence de Leval, Attilio Orazi, Robert P Hasserjian, Elizabeth L Courville, Yue Wu, Jihen Kourda, Christine G Roth, Jillian Brockmann, Alona Muzikansky, Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. Modern Pathology. ,vol. 26, pp. 751- 761 ,(2013) , 10.1038/MODPATHOL.2012.218
Sa A. Wang, Robert P. Hasserjian, Erythroid proliferations in myeloid neoplasms Human Pathology. ,vol. 43, pp. 153- 164 ,(2012) , 10.1016/J.HUMPATH.2011.08.008
Fumihiko Ishikawa, Shuro Yoshida, Yoriko Saito, Atsushi Hijikata, Hiroshi Kitamura, Satoshi Tanaka, Ryu Nakamura, Toru Tanaka, Hiroko Tomiyama, Noriyuki Saito, Mitsuhiro Fukata, Toshihiro Miyamoto, Bonnie Lyons, Koichi Ohshima, Naoyuki Uchida, Shuichi Taniguchi, Osamu Ohara, Koichi Akashi, Mine Harada, Leonard D Shultz, Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nature Biotechnology. ,vol. 25, pp. 1315- 1321 ,(2007) , 10.1038/NBT1350
Raya Mawad, Elihu H. Estey, Acute Myeloid Leukemia with Normal Cytogenetics Current Oncology Reports. ,vol. 14, pp. 359- 368 ,(2012) , 10.1007/S11912-012-0252-X
Constantine S. Tam, Roberto M. Nussenzveig, Uday Popat, Carlos E. Bueso-Ramos, Deborah A. Thomas, Jorge A. Cortes, Richard E. Champlin, Stefan E. Ciurea, Taghi Manshouri, Sherry M. Pierce, Hagop M. Kantarjian, Srdan Verstovsek, The natural history and treatment outcome of blast phase BCR-ABL- myeloproliferative neoplasms. Blood. ,vol. 112, pp. 1628- 1637 ,(2008) , 10.1182/BLOOD-2008-02-138230
Guido Marcucci, Kati Maharry, Michael D. Radmacher, Krzysztof Mrózek, Tamara Vukosavljevic, Peter Paschka, Susan P. Whitman, Christian Langer, Claudia D. Baldus, Chang-Gong Liu, Amy S. Ruppert, Bayard L. Powell, Andrew J. Carroll, Michael A. Caligiuri, Jonathan E. Kolitz, Richard A. Larson, Clara D. Bloomfield, Prognostic Significance of, and Gene and MicroRNA Expression Signatures Associated With,CEBPAMutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study Journal of Clinical Oncology. ,vol. 26, pp. 5078- 5087 ,(2008) , 10.1200/JCO.2008.17.5554