Microvessels Promote Motor Nerve Survival and Regeneration Through Local VEGF Release Following Ectopic Reattachment
作者： SHAWN E. BEARDEN , STEVEN S. SEGAL
DOI: 10.1080/10739680490517659
关键词:
摘要: Objectives: Nerves and blood vessels form a close association during embryogenesis. Growth guidance factors initially attributed to either nerves or are now known affect both tissues; prominent among these is vascular endothelial growth factor (VEGF). The authors investigated whether axons would associate with in regenerating system questioned VEGF integral neurotization following axotomy.Methods: In hamsters 8–12 weeks of age, the accessory nerve (CN XI) retractor muscle cheek pouch was cut proximal stump reattached ectopically onto muscle. Vascular casting immunolabeling were used quantify extent neurovascular regeneration. A role for using immunolocalization its receptor (sVEGFR2) as well local sequestration soluble (sVEGFR1).Results: Regenerating aligned microvessels vasa nervorum along “chaperone” region o...
sci-hub.se 参考文章(50)
J. T. Aitken, Growth of nerve implants in voluntary muscle. Journal of Anatomy. ,vol. 84, pp. 38- 49 ,(1950)
Marianne Kearney, Meredith Magner, Joseph Alroy, Lester S. Adelman, David H. Weinberg, Allan H. Ropper, Jeffrey M. Isner, Peter Schratzberger, Gabriele Schratzberger, Marcy Silver, Cynthia Curry, Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy Nature Medicine. ,vol. 6, pp. 405- 413 ,(2000) , 10.1038/74664
E. Tischer, R. Mitchell, T. Hartman, M. Silva, D. Gospodarowicz, J.C. Fiddes, J.A. Abraham, The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. Journal of Biological Chemistry. ,vol. 266, pp. 11947- 11954 ,(1991) , 10.1016/S0021-9258(18)99049-6
Philip Rosenstiel, Jobst Sievers, Ralph Lucius, Janka Held-Feindt, Claudia Röhl, Nils Warneke, Simone Böcker-Meffert, Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 2021- 2026 ,(2002)
K.A. Houck, D.W. Leung, A.M. Rowland, J Winer, N Ferrara, Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. Journal of Biological Chemistry. ,vol. 267, pp. 26031- 26037 ,(1992) , 10.1016/S0021-9258(18)35712-0
Bert Oosthuyse, Lieve Moons, Erik Storkebaum, Heike Beck, Dieter Nuyens, Koen Brusselmans, Jo Van Dorpe, Peter Hellings, Marchel Gorselink, Stéphane Heymans, Gregor Theilmeier, Mieke Dewerchin, Vincent Laudenbach, Patrick Vermylen, Harold Raat, Till Acker, Vicky Vleminckx, Ludo Van Den Bosch, Neil Cashman, Hajime Fujisawa, Maarten R. Drost, Raf Sciot, Frans Bruyninckx, Daniel J Hicklin, Can Ince, Pierre Gressens, Florea Lupu, Karl H. Plate, Wim Robberecht, Jean-Marc Herbert, Désiré Collen, Peter Carmeliet, Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration Nature Genetics. ,vol. 28, pp. 131- 138 ,(2001) , 10.1038/88842
G. Breier, W. Risau, S. Sterrer, U. Albrecht, Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation Development. ,vol. 114, pp. 521- 532 ,(1992) , 10.1242/DEV.114.2.521
Mariann Sondell, Göran Lundborg, Martin Kanje, Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System The Journal of Neuroscience. ,vol. 19, pp. 5731- 5740 ,(1999) , 10.1523/JNEUROSCI.19-14-05731.1999
Mariann Sondell, Frank Sundler, Martin Kanje, Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. European Journal of Neuroscience. ,vol. 12, pp. 4243- 4254 ,(2000) , 10.1046/J.0953-816X.2000.01326.X
Damien Bates, G.Ian Taylor, Joe Minichiello, Peter Farlie, Adam Cichowitz, Nadine Watson, Michael Klagsbrun, Roni Mamluk, Donald F Newgreen, Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1 Developmental Biology. ,vol. 255, pp. 77- 98 ,(2003) , 10.1016/S0012-1606(02)00045-3