Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
作者： Robert J. Motzer , Madhu Mazumdar , Jennifer Bacik , William Berg , Alison Amsterdam
DOI: 10.1200/JCO.1999.17.8.2530
关键词:
摘要: PURPOSE: To identify prognostic factors and a model predictive for survival in patients with metastatic renal-cell carcinoma (RCC). PATIENTS AND METHODS: The relationship between pretreatment clinical features was studied 670 advanced RCC treated 24 Memorial Sloan-Kettering Cancer Center trials 1975 1996. Clinical were first examined univariately. A stepwise modeling approach based on Cox proportional hazards regression then used to form multivariate model. performance of the internally validated through two-step nonparametric bootstrapping process. RESULTS: median time 10 months (95% confidence interval [CI], 9 11 months). Fifty-seven remain alive, follow-up survivors 33 months. Pretreatment associated shorter analysis low Karnofsky status ( 1.5...
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