Genetic variation in the COX-2 gene and the association with prostate cancer risk

摘要: COX-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins. The prostaglandins produced by are involved inflammation and pain response different tissues body. Accumulating evidence from epidemiologic studies, chemical carcinogen-induced rodent models clinical trials indicate that plays role human carcinogenesis overexpressed prostate cancer tissue. We examined whether sequence variants gene associated with risk. analyzed large population-based case–control study, Sweden (CAPS) consisting 1,378 cases 782 controls. evaluated 16 single nucleotide polymorphisms (SNPs) spanning entire 94 subjects control group. Five SNPs had minor allele frequency more than 5% our study population these were genotyped all case patients gene-specific haplotypes constructed. A statistically significant difference between controls was observed for 2 (+3100 T/G +8365 C/T), an odds ratio 0.78 (95% CI = 0.64–0.96) 0.65 0.45–0.94) respectively. In haplotype analysis, 1 carrying variant both +3100 C/T, 3%, also significantly decreased risk (p 0.036, global simulated p-value 0.046). This supports hypothesis variation within influence cancer. © 2006 Wiley-Liss, Inc.