PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.

摘要: Molecular imprinting, which involves the formation of artificial recognition elements or cavities with complementary shape and chemical functionality to target species, is a powerful method overcome number limitations associated natural antibodies. An important but often overlooked consideration in design biorecognition based on molecular imprinting nonspecific binding interfering species noncavity regions imprinted polymer. Here, we demonstrate universal method, namely, PEGylation polymer, minimize significantly enhance selectivity polymer for biomolecules. The binding, as quantified by localized surface plasmon resonance shift plasmonic nanorattles upon exposure common proteins, was found be more than 10 times lower compared non-PEGylated counterparts. demonstra...