Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: an immunohistochemical study.

摘要: We studied the topographic distribution and immunohistochemical characteristics of spinal cord neurofibrillary tangles (NFTs) in 6 patients with Guamanian amyotrophic lateral sclerosis (ALS) parkinsonism-dementia complex (PD) on Guam, using antibodies to tau protein ubiquitin. The NFTs were immunoreactive both antibodies, but staining for was more pronounced. As identified by this reactivity, all ALS PD cases examined showed NFTs. posterior horn had most anterior least. In located mainly marginal areas. Large cells few, if any, addition perikaryal NFTs, we observed tau-reactive neurites. Our results provide evidence that are not uncommon Guam they numerous than previously found conventional methods.