Chorionic villi sampling: cytogenetic and clinical findings in 500 pregnancies.

摘要: The cytogenetic findings were analysed in a series of 500 pregnancies which chorionic villi sampling was performed. In all cases direct method used, karyotyping being successful 481 (96.2%). main indication for maternal age over 36 (412 cases; 82.4%). Abnormal laboratory resulted 24 terminations pregnancy (4.8%); addition five unexpected balanced chromosome rearrangements detected. Twelve 15 discrepancies detected at amniocentesis, two after termination, and one spontaneous abortion. Complete follow up data available the first 250 patients, among whom nine (3.6%) ended abortion before 20th week. There no false negative findings. Seventy additional studies performed because failure or equivocal results, confirmation. Counselling should include possibility that subsequent amniocentesis may be needed mosaicism other abnormalities found. success rate accuracy samples by are acceptable but distinctly less than those cultured amniotic fluid cells.