Altered pulsatile secretion of luteinizing hormone in hypogonadal men with hyperprolactinaemia.
作者： S. J. WINTERS , P. TROEN
DOI: 10.1111/J.1365-2265.1984.TB03467.X
关键词: Internal medicine 、 Hormone 、 Follicle-stimulating hormone 、 Hyperprolactinaemia 、 Prolactin 、 Endocrinology 、 Bromocriptine 、 Gonadotropin 、 Luteinizing hormone 、 Testosterone 、 Medicine
摘要: To explore the mechanism for hypogonadism associated with prolactin hypersecretion in men we examined luteinizing hormone (LH) secretory profiles four hyperprolactinaemic before and during treatment bromocriptine. Pretreatment serum levels were increased 4-100 fold testosterone low three low-normal fourth subject. Mean LH frequency of spontaneous episodes was less than normal men. Bromocriptine reduced to normal; subsequently, libido potency improved markedly each man. The rise an increase mean concentrations pulse frequency. follicle-stimulating also bromocriptine treatment. Insofar as is believed reflect a discharge gonadotrophin releasing from anterior hypothalamus, our data suggest that major abnormality disorder neuroregulatory pulsatile gonadotrophin-releasing secretion.
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