Bronchial reactivity to histamine and bradykinin is unchanged after rhinovirus infection in normal subjects.

摘要: We investigated the effects of rhinovirus (RV) infection on airways reactivity. Twenty seven normal volunteers (11 atopic) were inoculated with RV 2 or EL. The provocative concentrations histamine and bradykinin required to produce a 15% fall in forced expiratory volume one second (FEV1) (PC15FEV1) measured before, 7 21 days after inoculation. Infection was determined by fourfold rise anti-viral antibody titre viral culture from nasal washings. Peak flow rate (PEF) recorded three before for All subjects underwent first two bronchial challenges, 22 third challenge. For whole group atopic subjects, there significant correlations between PC15 values (r = 0.82 r 0.85, respectively). infected; six had clinical colds. 16 infected who all median (range) PC15FEV1 challenges 36 (0.89-64), 62 (1.5-64) 34 (0.94-64) mg.ml-1, respectively, 32 mg.ml-1 each challenge (range: 0.015-32, 0.088-32 0.033-32). There no differences study group, those colds either subtype. change mean daily PEF infection. conclude that reactivity is unchanged experimental volunteers.