Low dose of acetylsalicylic acid and oxidative stress-mediated endothelial dysfunction in diabetes: a short-term evaluation

摘要: Current guidelines suggest the use of low doses acetylsalicylic acid (ASA) for patients with diabetes mellitus (DM) in primary prevention. However, evidences demonstrating beneficial effect ASA prevention are conflicting. In this pilot study, we evaluated a group diabetic patients, prevention, impact treatment on oxidative stress and vascular function. We enrolled 22 newly diagnosed without any previous clinical evidence cardiovascular disease, to receive, (100 mg/daily). tested, basal condition, after 4 weeks administration pharmacological washout, endothelial function, assessed by semipletysmographic method, measuring main parameters related it. As expected, treatment, induced significant reduction plasma thromboxane-A2, as consequence cyclooxygenase-1 inhibition. By contrast, significantly increased urine 8-iso-PGF2α, well-known prothrombotic molecule, parallel an increase NOX2 levels. The enhancement pathway is associated impairment vasodilation, reactive hyperemia index (RHI). washout reverted all condition. Our findings that utilization causes burden impairing Present data, if confirmed larger population, could permanently discourage DM.