Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function

摘要: Objectives The effect of aspirin upon platelet function is well documented although experimental studies suggest that may also affect oxidative stress, vascular inflammation, endothelial dysfunction and dysglycaemia. optimal dose for cardiovascular protection in type 2 diabetes still debated. We examined the effects different doses these novel markers risk any association between aspirin-mediated changes markers. Methodology Subjects with attended baseline evaluation including BMI, glycaemic lipid markers, (photoplethysmography), insulin resistance (HOMA), inflammation (sVCAM-1 Hs-CRP) stress [total anti-oxidant status (TAOS FRAP), whole blood total glutathione (GSH) assays]. then received random, sequential, blinded fashion 75 mg day−1, 300 3.6 g day−1 or placebo weeks a 2-week washout. above investigations were repeated after each intervention. Aspirin-related compared analysed using measures ANOVA. Results = 17 (M – 12; F 5), mean age 57.4 ± 9.1 years (mean 1 SD), HbA1c 63 13 mmol mol−1 (7.9 1.2%), cholesterol 4.57 1.01 l−1. At TAOS value was 59.3 9.7 μM AEAC (Ascorbate Equivalent Anti-oxidant Concentration), 302.2 183.3 l−1 FRAP 0.86 0.23 mM FeII. None had significant impact pressure, parameters, sensitivity FRAP, TAOS, GSH, function, control (fructosamine) HsCRP). Conclusions Aspirin exhibited no dose-dependent on (photoplethysmography) when used over period. (Clinical trials registration: NCT00898950, EUDRACT:2004-001418-14)