Renal effects of aspirin are clearly dose-dependent and are of clinical importance from a dose of 160 mg.

摘要: BACKGROUND: High doses of aspirin counteract the beneficial effects angiotensin-converting enzyme (ACE) inhibitors. It is not known how low-dose aspirin, with concomitant ACE-inhibitor treatment, affects renal function. AIM: To study different in elderly healthy volunteers who had an activated renin-angiotensin system. METHODS: Sixteen subjects each received two (0 and160 mg or 80 and 320 mg) after pre-treatment bendroflumethiazide enalapril, a randomised double-blind, cross-over fashion. RESULTS: Least square means observations 30 to 180 min dosing, showed that urine flow, GFR, excretion rates sodium, osmolality clearance free water were significantly decreased dose-dependent manner. Urine sodium rate lower vs. 0 mg, GFR was mg. rate, 160 CONCLUSION: The are clinical importance from dose adverse influence higher than should be taken into consideration patients heart failure. (Less)