Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors

摘要: Background By inhibiting prostaglandins, aspirin may be deleterious in heart failure (HF) and/or counteract angiotensin-converting enzyme (ACE) inhibitor efficacy. Conversely, clopidogrel has no effect on prostaglandin metabolism. Aim To investigate the of and brain natriuretic peptide (BNP) levels HF patients treated with ACE inhibitors. Methods 36 stable (65±13 years, 24 males/12 females, NYHA class II to IV, ejection fraction <40%, 13 coronary disease, all inhibitors) were enrolled this prospective, double-blind study randomised 325 mg/day or 75 for 14 days. BNP was determined at day 0 14. Results 19 17 clopidogrel. Baseline characteristics similar both groups. increased group from (107±103 144±149 pg/ml, p=0.04) whereas had (104±107 97±99 pg/ml respectively, p=0.61). Conclusion This demonstrates an adverse plasma inhibitors. In contrast effect.