Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction

摘要: Aims Cardiovascular risk factors are associated with decreased levels of circulating progenitor cells (CPC). The aim this study was to determine whether the number CPC is an independent correlate body mass index (BMI) and weight loss leads increase in CPC. Methods results CD34 positive KDR/CD34, CD133/CD34, CD117/CD34 double were measured by fluorescence activated cell sorting (FACS) analysis peripheral blood 149 volunteers (52.5 ± 12.0 years, BMI 21.5–52.7 kg/m2, mean 31.6 5.1 kg/m2) participating a reduction program offered German pharmacies. In addition, carotid intima media thickness (IMT) brachial artery flow-mediated dilatation determined. After diet sports for 6 months, 86 representing subjects re-evaluated (mean 5.8 5.2 kg). There inverse correlation between as well waist circumference CPC, especially positive, KDR/CD34 CD133/CD34 cells. This decrease obesity held true not only absolute numbers, but also relative fractions KDR, CD133, CD117 within cells, indicating specific down regulation these types. Multiple regression revealed that more prominent predictor than pressure, LDL cholesterol, triglycerides, fasting glucose, smoking. IMT increased dependence on ( P < 0.001) inversely correlated 0.05). diet, there significant which BMI. Also, accompanied = 0.015), 0.001). from achieved physical exercise or reduced calorie intake only. Conclusion Obesity numbers IMT. Diet lead count, might contribute