High-density lipoprotein cholesterol affects early endothelial progenitor cell number and endothelial function in obese women

摘要: Objective: In order to improve our understanding of high-density lipoprotein cholesterol (HDL-C) cardiovascular (CV) impact in obesity, the association HDL-C plasma level with circulating early endothelial progenitor cell (early-EPC) number and endothelium-dependent vasodilatation (EDV) obese women normal or high low-density (LDL-C) levels was evaluated. Design Methods: One hundred thirteen female subjects a control group 78 healthy were recruited. Circulating early-EPC assessed by single- two-color flow cytometric analyses fluorescence activated sorting (FACScan) cytometer. EDV evaluated as response ischemia strain gauge plethysmography. Results: Both significantly decreased compared group. Obese low showed further decrease presence both LDL-C plasmatic levels. subgroup, hypercholesterolemic nonhypercholesterolemic no difference number, whereas slight impairment present subjects. Conclusion: women, is associated impaired EDV, suggesting need assess whether evaluation may increase prognostic value stratification CV risk.