Interpreting Disparate Responses to Cancer Therapy: The Role of Human Population Genetics

摘要: Increasingly, investigators are recognizing differences in tumor biology, drug metabolism, toxicity, and therapeutic response among different patient populations receiving anticancer agents. These observations provide exciting opportunities to identify the factors most important for predicting individual variability pharmacologically relevant phenotypes consequently personalizing delivery of cancer therapy. Although pharmacogenomic may explain some these disparities, rigorous investigation both genetic nongenetic is variables optimal selection dosing treatment an patient. For example, pharmacogenetic tests currently used therapy, such as genotyping UGT1A1 reduce incidence severe toxicity irinotecan sequencing epidermal growth factor receptor from tumors somatic mutations conferring sensitivity tyrosine kinase inhibitors, were developed without initia...