The influence of bile salts on the distribution of simvastatin in the octanol/buffer system.
作者： Saša Vukmirović , Katarina Nikolić , Danica Agbaba , Momir Mikov , Maja Đanić
DOI: 10.3109/03639045.2015.1067626
关键词:
摘要: AbstractIntroduction: Distribution coefficient (D) is useful parameter for evaluating drugs permeability properties across biological membranes, which are of importance bioavailability. Given that bile acids intensively studied as drug permeation-modifying and -solubilizing agents, the aim this study was to estimate influence sodium salts cholic (CA), deoxycholic (DCA) 12-monoketocholic (MKC) on distribution simvastatin (SV) (lactone [SVL] acid form [SVA]) a highly lipophilic compound with extremely low water solubility bioavailability.Methods: LogD values SVA SVL or without were measured by liquid–liquid extraction in n-octanol/buffer systems at pH 5 7.4. SV concentrations aqueous phase determined HPLC-DAD. Chem3D Ultra program applied computation physico-chemical analyzed compounds their complexes.Results: Statistically significant decrease both logD ...
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