Pathobiology of germ cell tumors - Applying the gossip test!
作者： Leendert H. J. Looijenga , J. Wolter Oosterhuis
关键词:
摘要: Residual mature teratoma, a frequent finding in clinical pathology since the introduction of cisplatin-based chemotherapy, put Wolter Oosterhuis on track germ cell tumors (GCTs). These neoplasms borderland between developmental biology and oncology have fascinated him ever since. He tells story how GCTs brought contact with leading investigators field like Ivan Damjanov, Peter Andrews, Niels Skakkebaek. His fruitful line research was made possible through longstanding collaboration Bauke de Jong and, to this day, Leendert Looijenga who joined his group as student 1988. Probably their most important contribution is an integrated approach GCTs, combining epidemiology, pathology, (cyto)genetics molecular biology, that has resulted pathobiology-based classification five types. It relevance stimulates further these intriguing corresponding animal models.
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