The role of nitric oxide during embryonic wound healing

摘要: The study of the mechanisms controlling wound healing is an attractive area within field biology, with it having a potentially significant impact on health sector given current medical burden associated in elderly population. Healing complex process and includes many steps that are regulated by coding noncoding RNAs, proteins other molecules. Nitric oxide (NO) one these small molecule regulators its function has already been inflammation angiogenesis during adult healing. Our results showed NO also essential component embryonic scarless acts via previously unknown mechanism. mainly produced early phase crucial for expression genes However, we observed late healing, which occurs several hours after closure takes place under epidermis tissue remodelling dependent NO. We found multiple cellular metabolic pathways, particularly glucose metabolism pathway. This particular noteworthy as use donors have to be beneficial treatment chronic defects (including those diabetes) possible mechanism action follows describes new role may translate improved therapeutic treatments, especially individual suffering problematic