Blood pressure, atherosclerosis, and the incidence of age-related maculopathy : The Rotterdam Study

摘要: textabstractPURPOSE: To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS: The study was performed within the Rotterdam Study, a population-based, prospective cohort in Rotterdam, Netherlands. A total of 4822 subjects who at baseline were aged 55 years more, were free ARM, participated least one two follow-up examinations after a mean 2 6.5 years, included study. At baseline, presence determined. ARM assessed according to International Classification Grading System defined as large, soft drusen pigmentary changes; indistinct drusen; or atrophic neovascular macular degeneration. RESULTS: After follow-up 5.2 ARM diagnosed 417 subjects. Increased systolic pulse higher risk ARM. Adjusted for age, gender, smoking, high-density lipoprotein cholesterol, body mass index, diabetes mellitus, odds ratios (OR) per 10-mm Hg increase 1.08 (95% confidence interval [CI]: 1.03-1.14) 1.11 CI: 1.04-1.18), respectively. Moreover, different measures atherosclerosis An carotid wall thickness (OR 1 SD, 1.15; 95% CI: 1.03-1.28) increased of lowest compared highest tertile ankle-arm index had an OR 1.32 1.00-1.75). weak association found between aortic calcifications CONCLUSIONS: Elevated systolic pulse may increase development