The Ferrier Lecture, 1974: Body Temperature and Fever: Changes in our Views during the Last Decade

摘要: In the past, research on body temperature too often nearly became a branch of physics. A model from physics, thermostat, was taken to explain thermoregulatory functions anterior hypothalamus. change occurred when simple methods available for injecting drugs into cerebral ventricles unanaesthetized animals, and intraventricular injections noradrenaline 5-hydroxytryptamine were found affect temperature. These monoamines appear exert tonic influence by being released monoaminergic neurons ending in But they are not mediators endotoxin fever. Nor essential maintaining normal The fever E prostaglandins. They raise injected intraventricularly, during lipid cerebrospinal fluid, but disappear it is brought down antipyretics which inhibit prostaglandin synthesis. Many bodily functions, other than kept constant. It 'milieu interieur' Claude Bernard that factor apparently governs hypothalamus calcium ion concentration, since lack raises (and excess lowers)