Discussion of serotonin, norepinephrine, and fever.

摘要: Publisher Summary This chapter provides an account of the pharmacological experiments to study relation between brain monoamine levels and fever in rabbit, which states that balance release monoamines from cells anterior hypothalamus is mechanism whereby temperature maintained controlled. The also presents a relationship degree hyperthermia caused by leukocytic pyrogen selective depletion 5-HT p -chlorophenylalanine or NE α -methyl- -tyrosine. An interesting finding potentiation rabbit following injection precursor's 5-HTP dopa. results microinjections into conscious monkey are presented. In rhesus monkey, change depends critically on dose injected third cerebral ventricle hypothalamus. transfusion studies have revealed number facts, including first direct evidence functionally specific transmitter substance central nervous system animal.