Serrawettins and Other Surfactants Produced by Serratia

摘要: Serrawettins are nonionic biosurfactants produced by Serratia marcescens. Three molecular species, serrawettin W1, cyclo(d-3-hydroxydecanoyl-l-seryl)2; W2, d-3-hydroxydecanoyl-d-leucyl-l-seryl-l-threonyl-d-phenylalanyl-l-isoleucyl lactone; and W3, cyclodepsipeptide composed of five amino acids one dodecanoic acid, have been reported. rubidaea produces rubiwettin R1, linked d-3-hydroxy fatty RG1, β-glucopyranosyl acids. These mainly at 30°C, but not 37°C, secreted through extracellular vesicles on solid media. The contribution the to spreading growth in surface environments has determined, it is prominent under nutrient-poor conditions. Analyses S. marcescens mutants revealed involvement three novel genes for W1 production. gene pswP encodes a phosphopantetheinyl transferase group enzyme, swrW unimodular synthetase belonging nonribosomal peptide (NRPS) family, hexS LysR-type transcriptional regulator working as downregulator exolipids some exoenzymes. Autoinducer-dependent W2 production elucidated finding SwrI/SwrR (homolog LuxI/LuxR) N-acyl homoserine lactones study quorum-sensing controlled-swarming